The 80-year-old star, who plays Ken Barlow in the ITV show, has ended his two-year romance with TV weathergirl Emma, 44.
A source told The Sun: 'Emma and Bill drifted apart towards the end of last year and have made the decision to split up.
Love split: Bill Roache and Emma Jesson are said to have parted after two years of dating
Bill and Emma started dating in summer 2010 - over a year after his wife Sara's sudden death from a heart condition.
Last year, Bill hit the headlines for claiming he had slept with over 1,000 women during his youth.
His taste for the opposite sex led his Corrie co-stars to nickname him 'cock Roache'.
Heartbroken: Bill was devastated when his wife Sara died suddenly in 2009
'But what I did find out is, it does not bring you happiness and it is not the way to be.'
His first marriage to Anna Cropper broke down because of his infidelity.
The couple, who had been married for 13 years, had two children together, including the actor Linus Roache.
He went to marry second wife Sara in 1978, and he tamed his womanising ways.
They were happily wed for 31 years and had two children, before she collapsed and died at their Cheshire home in February 2000.
Volatile: Bill and her Corrie co-star Anne Kirkbride are well known for Ken and Deirdre's stormy relationship